Title of article :
An NMR method for determination of configuration of β-substituted carboxylic acids
Author/Authors :
Hoye، نويسنده , , Thomas R and Hamad، نويسنده , , Abdel-Sattar S and Koltun، نويسنده , , Dmitry O and Tennakoon، نويسنده , , Manomi A. Tennakoon، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
The absolute configuration of the stereogenic center at the β-position of a carboxylic acid can be determined via derivatization with chiral benzylic amines [PhCH(Me)NH2 or 1-NpCH(Me)NH2]. Acids of known configuration and with a variety of β-substituents were subjected to derivatization. Analysis of the signs of the chemical shift differences of substituent protons permits determination of the absolute configuration.
Keywords :
NMR spectroscopy , Stereochemistry , carboxylic acids , configuration
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
