tert-Butoxycarbamate group: a useful protecting group for the synthesis of orthogonally protected ‘tropane-like’ scaffolds

The first synthesis of N-Boc-protected tropanes by a [4+3] cycloaddition reaction is described. The Boc group has been cleanly removed demonstrating that this group would be very useful for the synthesis of ‘tropane-like’ scaffolds for combinatorial chemistry.