Title of article :
Asymmetric synthesis of 1,3- and 1,3,4-substituted pyrrolidines
Author/Authors :
Lin، نويسنده , , Jing and Chan، نويسنده , , Wing-Hong and Lee، نويسنده , , Albert W.M and Wong، نويسنده , , Wai Yeung and Huang، نويسنده , , Pei Qiang، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
Diastereoselective alkylation of N-acylnorbornene sultams 2 afforded a variety of enantiomerically pure products 3a–3e. Reduction with LiAlH4 (LAH) followed by ditosylation furnished chiral 1,4-ditosylates 5a–5e which underwent a cyclization reaction with primary amines to afford chiral 1,3- and 1,3,4-substituted pyrrolidines.
Keywords :
cyclization , Pyrrolidines , sultams , asymmetric synthesis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
