Title of article
Regioselective lactonization of naphthoquinones: synthesis and antitumoral activity of the WS-5995 antibiotics
Author/Authors
Ghassan Qabaja، نويسنده , , Ghassan and M. Perchellet، نويسنده , , Elisabeth M. Perchellet، نويسنده , , Jean-Pierre and Jones، نويسنده , , Graham B، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
3007
To page
3010
Abstract
An acid promoted quinolactonization of naphthoquinones has been developed, providing direct access to either ortho or para isomers as desired. Application of this methodology in syntheses of the antibiotics WS-5995A, WS-5995C and functional analogs is demonstrated. Preliminary antitumoral activity of the analogs is presented together with electrochemical analysis.
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1637161
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