Title of article
Solid phase synthesis of sulfahydantoins
Author/Authors
Albericio، نويسنده , , Fernando and Garcia، نويسنده , , Javier and Michelotti *، نويسنده , , Enrique L and Nicolلs، نويسنده , , Ernesto and Tice *، نويسنده , , Colin M، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
3
From page
3161
To page
3163
Abstract
A five step solid phase synthesis of 2-unsubstituted 1,2,5-thiadiazolidin-3-one 1,1-dioxides (sulfahydantoins) from Nα-FMOC-amino acids and aromatic aldehydes is described. The key step is the base mediated cyclitive cleavage of a resin bound Nα-(aminosulfonyl)-Nα-benzyl-amino acid to afford the desired product. This synthesis allows the preparation of a diverse library of compounds based on this heterocycle.
Keywords
amino acids , Combinatorial chemistry , Libraries , thiadiazoles , cyclitive cleavage
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1637258
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