Title of article
Direct vinylogous aldol addition of γ-butyrolactones and γ-butyrolactams
Author/Authors
Bella، نويسنده , , Marco and Piancatelli *، نويسنده , , Giovanni and Squarcia، نويسنده , , Antonella and Trolli، نويسنده , , Carla، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
3669
To page
3672
Abstract
Deprotonation of N-benzyl-3-phenylselenylpyrrol-2(5H)-one 3 and furan-2(5H)-one 4 and reaction with aldehydes affords regioselectively 5-(1′-hydroxy)-γ-butyrolactones and the aza-analogous butyrolactams with good diastereoisomeric excesses. The presence of Lewis acids enhances the diastereoisomeric ratios.
ethodology is an alternative to Lewis acid mediated silyloxydiene condensation.
Keywords
pyrrolidones , regioselective aldol reaction , furanones
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1637557
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