Author/Authors :
Koksch، نويسنده , , Beate and Mütze، نويسنده , , Kerstin and Osipov، نويسنده , , Sergej N and Golubev، نويسنده , , Alexander S and Burger، نويسنده , , Klaus، نويسنده ,
Abstract :
A new approach to the synthesis of dipeptides containing up to three trifluoromethyl groups has been developed. The method is based on a [4+1]-cycloaddition reaction of hexafluoroacetone or methyl 3,3,3-trifluoropyruvate derived N-acylimines and α-amino acid isocyanides. Acidic hydrolysis of the cycloadducts gives the trifluoromethylated dipeptides in good yields.
