Title of article
Pyrrolidines bearing a quaternary α-stereogenic center. Part 2: Access to proline chimeras, stereoselective approach and mechanistic aspects
Author/Authors
Trancard، نويسنده , , Delphine and Tout، نويسنده , , Jean-Baptiste and Giard، نويسنده , , Thierry and Chichaoui، نويسنده , , Ilhame and Cahard، نويسنده , , Dominique and Plaquevent، نويسنده , , Jean-Christophe، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
3843
To page
3847
Abstract
The present work describes the access to various proline chimeras bearing a quaternary α-stereogenic center, via the Duhamel ring contraction of heterocyclic enamines. Attempts to induce diastereoselectivity are reported. The ‘chiral enamine’ strategy afforded the required aminoaldehydes with diastereomeric ratios as high as 85:15.
Keywords
diastereoselection , Pyridinium salts , enamines , Pyrrolidines , amino aldehydes
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1637637
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