Title of article
Stereochemistry and total synthesis of janolusimide, a tripeptide marine toxin
Author/Authors
Giordano، نويسنده , , Assunta and Della Monica، نويسنده , , Carmela and Landi، نويسنده , , Francesco and Spinella *، نويسنده , , Aldo and Sodano *، نويسنده , , Guido، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
3979
To page
3982
Abstract
The stereochemistry of janolusimide, a lipophilic tripeptide marine toxin, has been fully elucidated by stereoselective synthesis of the lactam component (5S)-3,3′-dimethyl-5-isopropylpyrrolidin-2,4-dione. The peptide was then synthesized in 13 steps and in 0.8% total yield.
Keywords
Marine metabolites , molluscs , Imides , Peptides
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1637696
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