Author/Authors :
Okamura، نويسنده , , Hiroaki and Shimizu، نويسنده , , Hideki and Nakamura، نويسنده , , Yasuko and Iwagawa، نويسنده , , Tetsuo and Nakatani، نويسنده , , Munehiro، نويسنده ,
Abstract :
An asymmetric synthesis of the key intermediate of RPR 107880, a substance P antagonist, using a base-catalyzed Diels–Alder reaction of 3-hydroxy-2-pyrone and N-benzylmaleimide is described.
Keywords :
base-catalyzed Diels–Alder reaction , asymmetric synthesis , substance P , RPR 107880
