A new method for the formation of 2,4-disubstituted oxazoles: internal transfer of oxidation state through a molecular framework

A new method for the synthesis of 2,4-disubstituted oxazoles is described from readily available starting materials. The synthesis avoids the necessity for the oxidation of an oxazoline to an oxazole by utilising an internal transfer of oxidation state across a molecular framework and has been performed on multigram scale.