Title of article
Design and synthesis of a novel photoaffinity taxoid as a potential probe for the study of paclitaxel–microtubules interactions
Author/Authors
Lin، نويسنده , , Songnian and Fang، نويسنده , , Kan and Hashimoto، نويسنده , , Masaru and Nakanishi، نويسنده , , Koji and Ojima، نويسنده , , Iwao، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
4287
To page
4290
Abstract
A novel and non-radioactive bifunctional photoaffinity probe (BPP) for the study of paclitaxel–microtubules interactions is designed and synthesized. This new BPP-taxoid bears a 3-nitro-5-trifluoromethyldiazirinyl-phenoxyacetyl group at C-3′N for photoaffinity/photocleavage and a biotin subunit at C-7 for affinity chromatography.
Keywords
Taxoid , bifunctional probe , Diazirine , Biotin , photoaffinity label
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1637840
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