Title of article
A convenient method for synthesis of optically active 2,3-methanopipecolic acid
Author/Authors
Matsumura، نويسنده , , Yoshihiro and Inoue، نويسنده , , Mayumi and Nakamura، نويسنده , , Yasuharu and Talib، نويسنده , , Idi Ludwig and Maki، نويسنده , , Toshihide and Onomura، نويسنده , , Osamu، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
4619
To page
4622
Abstract
2,3-Didehydro-1,2-bis(methoxycarbonyl)-6-methoxypiperidine (4), prepared from l-lysine by using electrochemical oxidation, was cyclopropanated with high diastereoselectivity (96.6% de), and the cyclopropanated product was transformed to optically active 2,3-methanopipecolic acid (1). In this transformation, the 6-methoxy group of 4 was found to be an effective chiral auxiliary.
Keywords
amino acids and derivatives , Electrochemical reactions , asymmetric synthesis , Cyclopropanation
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1637979
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