Title of article :
A convenient method for synthesis of optically active 2,3-methanopipecolic acid
Author/Authors :
Matsumura، نويسنده , , Yoshihiro and Inoue، نويسنده , , Mayumi and Nakamura، نويسنده , , Yasuharu and Talib، نويسنده , , Idi Ludwig and Maki، نويسنده , , Toshihide and Onomura، نويسنده , , Osamu، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
2,3-Didehydro-1,2-bis(methoxycarbonyl)-6-methoxypiperidine (4), prepared from l-lysine by using electrochemical oxidation, was cyclopropanated with high diastereoselectivity (96.6% de), and the cyclopropanated product was transformed to optically active 2,3-methanopipecolic acid (1). In this transformation, the 6-methoxy group of 4 was found to be an effective chiral auxiliary.
Keywords :
amino acids and derivatives , Electrochemical reactions , asymmetric synthesis , Cyclopropanation
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
