Title of article
Chemoselective methylation of amides and heterocycles using chloromethyldimethylsilyl chloride
Author/Authors
Bassindale، نويسنده , , Alan R and Parker، نويسنده , , David J and Patel، نويسنده , , Pravin and Taylor، نويسنده , , Peter G، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
4933
To page
4936
Abstract
The reaction of chloromethyldimethylsilyl chloride with an amide generates a pentacoordinate N-(amidomethyl)-halosilane that can be desilylated with cesium fluoride to give the N-methyl amide. This provides a selective method for the monoalkylation of amides in the presence of other, more nucleophilic groups.
Keywords
Amides , silicon halides , hypervalent elements , Alkylation
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1638103
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