Title of article
Solid-phase synthesis of substituted 2-aminomethylbenzimidazoles
Author/Authors
Kilburn، نويسنده , , John P and Lau، نويسنده , , Jesper and Jones، نويسنده , , Raymond C.F. Jones، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
3
From page
5419
To page
5421
Abstract
Resin-bound 4-fluoro-3-nitrobenzoic acid is converted by reaction with a range of amines and reduction, to substituted 1,2-diaminobenzenes, whose reaction with activated amino acids followed by acid-catalyzed cyclisation gave resin-bound benzimidazoles; Fmoc-deprotection, acylation and TFA-mediated cleavage gave substituted 2-aminomethylbenzimidazoles via a new solid support strategy.
Keywords
Benzimidazole , Combinatorial chemistry , solid-phase synthesis
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1638221
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