Author/Authors :
Chen، نويسنده , , Bang-Chi and Bednarz، نويسنده , , Mark N. and Zhao، نويسنده , , Rulin and Sundeen، نويسنده , , Joseph E and Chen، نويسنده , , Ping and Shen، نويسنده , , Zhongqi and Skoumbourdis، نويسنده , , Amanda P and Barrish، نويسنده , , Joel C، نويسنده ,
Abstract :
A new facile method for the preparation of 1-arylimidazole-5-carboxylates was developed. The new method involved reaction of anilines and ethyl glyoxylate in methanol to give α-anilino-α-methoxyacetates followed by cyclization with TosMIC, affording 1-arylimidazole-5-carboxylates in two steps in 40–94% overall yields.
