Title of article
A norbornyl route to azasugars: a new synthesis of deoxynojirimycin analogues
Author/Authors
Mehta، نويسنده , , Goverdhan and Mohal، نويسنده , , Narinder، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
5741
To page
5745
Abstract
A new synthesis of deoxynojirimycin (DNJ) analogues (galacto- and altrose configuration) has been achieved through a functionalized cyclopentene derivative crafted from the norbornyl system, employing double reductive amination as the key step. The new DNJ analogues have been evaluated against various glycosidases and found to be moderate to strong inhibitors.
Keywords
azasugars , Glycosidase inhibitors , Osmylation , reductive amination
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1638287
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