A novel convergent approach to trans-fused polyether frameworks based on the reaction of vinylstannanes and triflates and its application to a synthetic study of the EFGH ring system of gambierol

A new strategy for the convergent assembly of six-membered polycyclic ether ring fragments has been developed based upon the novel reaction between vinylstannanes with triflates in the presence of a strong base. The application of the present method has allowed for a synthetic study of the EFGH ring of gambierol to be achieved.