Author/Authors :
Coleman، نويسنده , , Paul J and Hutchinson، نويسنده , , John S. and Hunt، نويسنده , , Cecilia A and Lu، نويسنده , , Ping and Delaporte، نويسنده , , Enock and Rushmore، نويسنده , , Tom، نويسنده ,
Abstract :
Efficient stereoselective syntheses of 5- and 6-[2,3]-dihydrobenzofuran β-amino acids are described. These 3-aryl β-amino acids are aspartic acid mimetics that are structurally related to known benzodioxole systems. In many cases, the benzodioxole can inhibit and induce cytochrome P-450; neither of these dihydrobenzofuran β-amino esters is a potent inhibitor of several human P-450 enzymes.
