Title of article
Synthesis of a rhazinilam analogue acting as an inhibitor of tubulin assembly
Author/Authors
Dupont، نويسنده , , Christophe and Guénard، نويسنده , , Daniel and Thal، نويسنده , , Claude and Thoret، نويسنده , , Sylviane and Guéritte، نويسنده , , Françoise، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
5853
To page
5856
Abstract
The synthesis of a di-nor-secorhazinilam analogue is described. This phenylpyrrole compound has been prepared by a Susuki cross-coupling reaction between 1,2,5 trisubstituted pyrrole halides and 2-N-(tert-butoxycarbonyl)aminophenyl boronic acid. In contrast to rhazinilam, this new phenylpyrrole inhibits the assembly of tubulin into microtubules.
Keywords
phenylpyrroles , rhazinilam , biological activity tubulin , coupling reactions
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1638310
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