Title of article
An efficient synthesis of 2-(3-(4-amidinophenylcarbamoyl)naphthalen-2-yl)-5-((2,2-methylpropyl)carbamoyl)benzoic acid: a factor VIIa inhibitor discovered by the Ono Pharmaceutical Company
Author/Authors
Kohrt، نويسنده , , Jeffrey T and Filipski، نويسنده , , Kevin J and Rapundalo، نويسنده , , Stephen T and Cody، نويسنده , , Wayne L and Edmunds، نويسنده , , Jeremy J، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
6041
To page
6044
Abstract
A small molecule factor VIIa inhibitor has recently been reported by the Ono Pharmaceutical Company. Herein, we outline an efficient and convergent, synthetic route that relies upon a palladium-catalyzed Stille coupling reaction as a key step for the synthesis of the inhibitor.
Keywords
anticoagulant , palladium catalyzed cross-coupling , Stillie coupling , Factor VIIa
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1638350
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