Author/Authors :
Benayoud، نويسنده , , Farid and Abouabdellah، نويسنده , , Ahmed and Richard، نويسنده , , Cyrille and Bonnet-Delpon، نويسنده , , Danièle and Bégué، نويسنده , , Jean-Pierre and Levasseur، نويسنده , , Danielle and Boutaud، نويسنده , , Olivier and Schuber، نويسنده , , Francis، نويسنده ,
Abstract :
Trifluoromethyl ketones 1 and 2, have been prepared from trisnorsqualene aldehyde 3. These compounds and their corresponding alcohols 4 and 7 have been found to be good inhibitors of the biosynthesis of cholesterol in HepG2 cells. The inhibition is correlated with a decrease of the HMG-CoA reductase activity, probably resulting from the transformation of the fluorinated compounds into their corresponding oxysterols which could act as repressors of that enzyme.
