Title of article
Diels–Alder reactions of activated furans to cyclopentenone derivatives: a regiodivergent Diels–Alder approach towards polyfunctionalised cis-hydrindanones
Author/Authors
Trembleau، Alain نويسنده , , Laurent and Patiny، نويسنده , , Luc and Ghosez، نويسنده , , Léon، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
5
From page
6377
To page
6381
Abstract
Cycloaddition of activated furans 10 to 4-methoxycyclopent-2-enone was unexpectedly found to take place with a regioselectivity opposed to that predicted by FMO theory. The reaction represents a direct route towards polyfunctionalised cis-hydrindanones which are key intermediates for the synthesis of ottelione A, a potent inhibitor of tubulin polymerisation.
Keywords
cis-hydrindanones , Cycloadditions , Furans , high-pressure chemistry , otteliones
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1638448
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