Artificial holoenzymes for benzoin condensation using thiazolio-appended β-cyclodextrin dimers

Artificial holoenzymes for benzoin condensation were synthesized using thiazolio-appended β-cyclodextrin dimers. The dimer with an l-aspartic acid residue as a linker for connecting two β-cyclodextrin units caused a 26-fold acceleration in the benzoin condensation, whereas the dimer with the linker of a l-glutamic acid residue caused only a 7-fold acceleration, indicating that the linker length of the dimer is an important factor in this artificial holoenzyme.