Author/Authors :
Roulland، نويسنده , , Emmanuel and Bertounesque *، نويسنده , , Emmanuel and Huel، نويسنده , , Christiane and Monneret، نويسنده , , Claude، نويسنده ,
Abstract :
Based on a Wittig olefination strategy, the first synthesis of picropodophyllin homolactone 2 is described in nine steps and 30% overall yield from podophyllotoxine 1. The relative configuration of 2 was unambiguously determined using 2D NOESY NMR and a Monte Carlo search protocol. This work corrects the literature on the synthesis of 2.
