Title of article :
Pd-catalyzed hydrogenolysis of 4,5-epoxy-2-alkenoates: model study of the acyl side-chain of polyoxypeptin
Author/Authors :
Noguchi، نويسنده , , Yasuo and Yamada، نويسنده , , Tatsuhiro and Uchiro، نويسنده , , Hiromi and Kobayashi، نويسنده , , Susumu، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
Palladium-catalyzed hydrogenolysis of 4,5-epoxy-2-alkenoates to 5-hydroxy-2-alkenoates was examined, and it was shown that the (Z)-alkenoate with a bulky substituent at C-4 underwent hydrogenolysis with a decrease in the stereospecificity. Mechanistic considerations and steps for improvement of the stereospecificity are also presented.
Keywords :
polyoxypeptin , ?–?–? interconversion , Pd-catalyzed hydrogenolysis , 4 , 5-epoxy-2-alkenoate
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
