Title of article :
Synthetic study of polyoxypeptin: stereoselective synthesis of the acyl side-chain segment
Author/Authors :
Noguchi، نويسنده , , Yasuo and Yamada، نويسنده , , Tatsuhiro and Uchiro، نويسنده , , Hiromi and Kobayashi، نويسنده , , Susumu، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
The first synthesis of the acyl side-chain segment of polyoxypeptin, a potent inducer of apoptosis in human pancreatic carcinoma AsPC-1, was accomplished. The key feature of the present synthesis is the stereospecific palladium-catalyzed hydrogenolysis of (Z)-alkenyloxirane to anti-hydroxyalkenoate by an improved method.
Keywords :
polyoxypeptin , Pd-catalyzed hydrogenolysis , alkenyl oxirane
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
