Title of article :
Application of Rh-catalyzed cyclization for the construction of three consecutive chiral carbons in 4,9-dimethylspiro[4.4]nonane-2,7-dione
Author/Authors :
Takahashi، نويسنده , , Miyuki and Tanaka*، نويسنده , , Masakazu and Sakamoto، نويسنده , , Eishi and Imai، نويسنده , , Masanori and Matsui، نويسنده , , Akiko and Funakoshi، نويسنده , , Kazuhisa and Sakai، نويسنده , , Kiyoshi and Suemune، نويسنده , , Hiroshi، نويسنده ,
Abstract :
Asymmetric cyclization using Rh-complexes has been applied to the synthesis of 4,9-dimethylspiro[4.4]nonane-2,7-diones. The spiro[4.4]nonane skeleton bearing three consecutive chiral carbons could be stepwisely constructed from an identical starting material by the combination of a cationic Rh[(S)-BINAP]ClO4 and a neutral RhCl(PPh3)3. The relationship between the stereochemistry of the spirodiketones and the Rh-complex was also discussed.
Keywords :
cyclization , spiro compounds , Rhodium , Asymmetric reactions
