Title of article
Synthesis of aspartimide-free protected peptides on base-labile functionalized resins
Author/Authors
Rabanal، نويسنده , , Francesc and Pastor، نويسنده , , Jose J and Nicolلs، نويسنده , , Ernesto and Albericio، نويسنده , , Fernando and Giralt*، نويسنده , , Ernest، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
8093
To page
8096
Abstract
Aspartimide prone sequence containing protected peptides are successfully synthesized in solid phase by using the bifunctional linker N-[(9-hydroxymethyl)-2-fluorenyl] succinamic acid (HMFS) in combination with morpholine as the cleavage reagent. Access to high purity peptide synthons opens a straightforward way to the synthesis of large proteins by convergent strategies.
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1639334
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