Author/Authors :
Matsumoto، نويسنده , , Takashi and Yamaguchi، نويسنده , , Hiroki C. Tanabe، نويسنده , , Mitsujiro and Yasui، نويسنده , , Yoshizumi and Suzuki، نويسنده , , Keisuke، نويسنده ,
Abstract :
The first total synthesis of aquayamycin (1) has been accomplished. The crucial steps include (1) the Hauser reaction between 3-(phenylsulfonyl)phthalide 3 and cyclohexenone 4 to make up the linear BCD tricycle, and (2) the intramolecular pinacol coupling of keto aldehyde 7 to the full tetracyclic framework.
