Highly regio- and stereo-controlled Pd(0)-catalyzed nucleophilic substitution reaction for the synthesis of optically active γ-fluoroalkylated allylic alcohols

Pd(0)-catalyzed nucleophilic substitution reaction of optically active α-(fluoroalkyl)allyl mesylates with various types of carboxylates proceeded regioselectively to afford the corresponding chiral γ-fluoroalkylated allylic alcohol derivatives in excellent yields without any loss of optical purities.