Author/Authors :
Keck، نويسنده , , Gary E and Sanchez، نويسنده , , Carina and Wager، نويسنده , , Carrie A، نويسنده ,
Abstract :
An efficient macrolactonization procedure using a polymer bound carbodiimide is described. The procedure uses the polymer supported reagent as a replacement for dicyclohexylcarbodiimide and thus considerably simplifies the workup for such reactions. Partitioning between macrolactone and diolide is shown to depend upon the equivalents of reagent used in cases for which lactonization is difficult.
