Title of article :
Triplex-forming enhancement with high sequence selectivity by single 2′-O,4′-C-methylene bridged nucleic acid (2′,4′-BNA) modification
Author/Authors :
Obika، نويسنده , , Satoshi and Hari، نويسنده , , Yoshiyuki and Sugimoto، نويسنده , , Tomomi and Sekiguchi، نويسنده , , Mitsuaki and Imanishi، نويسنده , , Takeshi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
Triplex-forming ability of the oligonucleotides containing one 2′-O,4′-C-methyleneribonucleic acid (2′,4′-BNA) unit was investigated by measurement of the melting temperature (Tm), and the 2′,4′-BNA modification promoted the marked triplex stabilization in a highly sequence-selective manner.
Keywords :
nucleic acid analogues , triplex , Antigene , melting temperature (Tm)
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
