Title of article :
Aqueous trifluoroacetic acid—an efficient reagent for exclusively cleaving the 5′-end of 3′,5′-TIPDS protected ribonucleosides
Author/Authors :
Zhu، نويسنده , , Xue-Feng and Williams، نويسنده , , Howard J and Scott، نويسنده , , A.Ian، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Abstract :
The 5′-silyl ethers of 3′,5′-TIPDS protected nucleosides can be selectively cleaved in excellent yields (95–99%) by treatment with TFA–H2O–THF (1:1:4) at 0°C.
Keywords :
nucleosides , Nucleotides , protection groups , Hydrolysis , Cleavage reactions , regiospecificity
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
