Title of article :
New synthesis of 5-amino-4-hydroxy-2,6-dimethylheptanoic acid, a hydroxyethylene isostere of the Val-Ala dipeptide
Author/Authors :
Benedetti، نويسنده , , Fabio and Maman، نويسنده , , Paolo and Norbedo، نويسنده , , Stefano، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2000
Pages :
4
From page :
10075
To page :
10078
Abstract :
Two stereoisomers of the title compound have been synthesized from the methyl ester of N-Boc L-valine. The aminoester was initially converted into an α′-amino α,β-unsaturated ketone via a phosphonoketone and a Horner–Emmons olefination with acetaldehyde. Hydrocyanation of the enone with diethylaluminium cyanide and functional group conversions gave the hydroxyaminoacids protected as oxazolidines or as lactones.
Journal title :
Tetrahedron Letters
Serial Year :
2000
Journal title :
Tetrahedron Letters
Record number :
1640668
Link To Document :
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