An efficient method for opening nonactivated aziridines with TMS azide: application in the synthesis of chiral 1,2-diaminocyclohexane

A variety of N-substituted aziridines have been opened with TMS azide in MeCN at rt in the absence of any Lewis acid. The reaction was extended to the synthesis of (R,R)- and (S,S)-1,2-diaminocyclohexane.