Title of article
Double stereodifferentiation in asymmetric dihydroxylation: application to the first diastereoselective synthesis of l-xylo-[2R,3S,4S]-C18-phytosphingosine
Author/Authors
Fernandes، نويسنده , , Rodney A and Kumar، نويسنده , , Pradeep، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2000
Pages
4
From page
10309
To page
10312
Abstract
The first diastereoselective synthesis of l-xylo-(2R,3S,4S)-C18-phytosphingosine (1) has been achieved by double stereodifferentiation of enantiomerically enriched terminal olefin 14 using (DHQD)2–PHAL ligand in an asymmetric dihydroxylation with a diastereomeric ratio of 83:17. This phytosphingosine was fully characterized by the physical and spectral data of the corresponding tetraacetate 21.
Keywords
Asymmetric dihydroxylation , phytosphingosines , diastereoselective synthesis , double stereodifferentiation , sphingolipids
Journal title
Tetrahedron Letters
Serial Year
2000
Journal title
Tetrahedron Letters
Record number
1640817
Link To Document