Title of article
Solid-phase combinatorial synthesis of benzothiazole and 2,3-dihydro-[1,5]-benzothiazepine derivatives
Author/Authors
Lee، نويسنده , , Cheng Leng and Lam، نويسنده , , Yulin and Lee، نويسنده , , Soo-Ying، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
109
To page
111
Abstract
Bis-(2-nitro-4-carboxyphenyl) disulfide was loaded on Wang resin and Rink amide resin. The nitro group was reduced to its amine with concomitant cleavage of the disulfide bond using SnCl2·2H2O to afford 2. Condensation of an aldehyde and nucleophilic attack on an α,β-unsaturated ketone, followed by TFA cleavage from the resin, gave benzothiazole 3 and 2,3-dihydro-[1,5]-benzothiazepine 4, respectively.
Keywords
solid-phase synthesis , benzothiazole , 2 , 3-dihydro-1 , 5]-benzothiazepine
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1640932
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