Author/Authors :
Notz، نويسنده , , Wolfgang and Sakthivel، نويسنده , , Kandasamy and Bui، نويسنده , , Tommy and Zhong، نويسنده , , Guofu and Barbas III، نويسنده , , Carlos F، نويسنده ,
Abstract :
Three chiral cyclic secondary amines are shown to be catalysts for the direct asymmetric Mannich-type reaction of acetone with a variety of preformed aldimines derived from o-anisidine. A simple one-pot three-component reaction procedure consisting of aldehyde, acetone, p-anisidine and an amine catalyst provides the corresponding β-amino ketones with 50–89% ee under very mild conditions.
