Title of article :
Synthesis of (Z)-fluoroalkene dipeptide isosteres utilizing organocopper-mediated reduction of γ,γ-difluoro-α,β-enoates
Author/Authors :
Otaka، نويسنده , , Akira and Watanabe، نويسنده , , Hideaki and Mitsuyama، نويسنده , , Etsuko and Yukimasa، نويسنده , , Akira and Tamamura، نويسنده , , Hirokazu and Fujii، نويسنده , , Nobutaka، نويسنده ,
Abstract :
γ,γ-Difluoro-α,β-enoates are reduced with organocopper reagents to afford the corresponding γ-fluoro-β,γ-enoates. This organocopper-mediated reduction was applied to the synthesis of (Z)-fluoroalkene dipeptide isosteres.
