Author/Authors :
Kane، نويسنده , , Vinayak V and Gerdes، نويسنده , , Anton and Grahn، نويسنده , , Walter and Ernst، نويسنده , , Ludger and Dix، نويسنده , , Ina and Jones، نويسنده , , Peter G and Hopf، نويسنده , , Henning، نويسنده ,
Abstract :
Two syntheses of (±)-[2.2]paracyclophane-4-thiol have been accomplished in two and five steps, with overall yields of 46 and 31%, respectively, from [2.2]paracyclophane. The strategy involves two key reactions: (a) a lithium aluminium hydride reduction of the disulphide of [2.2]paracyclophane and (b) the use of a Newman–Kwart reaction for the conversion of [2.2]paracyclophane-4-ol to [2.2]paracyclophane-4-thiol.
