Title of article
A novel entry into a new class of cyclophane derivatives: synthesis of (±)-[2.2]paracyclophane-4-thiol
Author/Authors
Kane، نويسنده , , Vinayak V and Gerdes، نويسنده , , Anton and Grahn، نويسنده , , Walter and Ernst، نويسنده , , Ludger and Dix، نويسنده , , Ina and Jones، نويسنده , , Peter G and Hopf، نويسنده , , Henning، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
373
To page
376
Abstract
Two syntheses of (±)-[2.2]paracyclophane-4-thiol have been accomplished in two and five steps, with overall yields of 46 and 31%, respectively, from [2.2]paracyclophane. The strategy involves two key reactions: (a) a lithium aluminium hydride reduction of the disulphide of [2.2]paracyclophane and (b) the use of a Newman–Kwart reaction for the conversion of [2.2]paracyclophane-4-ol to [2.2]paracyclophane-4-thiol.
Keywords
Newman–Kwart reaction
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1641145
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