Title of article
The Baylis–Hillman chemistry in aqueous media: a convenient synthesis of 2-methylenealkanoates and alkanenitriles
Author/Authors
Basavaiah، نويسنده , , Deevi and Kumaragurubaran، نويسنده , , Nagaswamy، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
477
To page
479
Abstract
A convenient, general and efficient synthesis of 2-methylenealkanoates and alkanenitriles is accomplished via the regioselective nucleophilic (SN2′) addition of hydride ion from NaBH4 to (2Z)-2-(bromomethyl)alk-2-enoates and 2-(bromomethyl)alk-2-enenitriles respectively in the presence of DABCO in environment friendly aqueous media. Synthesis of two hypoglycemic agents is also described.
Keywords
Baylis–Hillman chemistry , 2-methylenealkanoates , Alkanenitriles , regioselectivity
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1641234
Link To Document