Total synthesis of (+)-crocacin C

The first synthesis of (+)-crocacin C (3) in optically pure form is achieved following a convergent strategy. The synthesis also establishes the absolute stereochemistries of this novel class of potent antifungal and highly cytotoxic compounds. The naturally occurring crocacin C has (6S,7S,8R,9S) configuration, which is also the same for other congeners of the family, crocacins A, B and D.