A convenient method for the alkylation of sulfamides using alkyl bromides and Mitsunobu betaine

The alkylation of N-Boc-N′-(2-chloroethyl)sulfamide 1 by electron-deficient alkyl bromides using the Mitsunobu reagent as mild base is described. This method was also applied to the N-glycosylation of various carbohydrates and was anomerically selective.