Synthesis of optically pure N-Boc-protected (2R,3R)- and (2R,3S)-3-fluoroprolines

Non-protein amino acids (2R,3R)- and (2R,3S)-3-fluoroprolines were synthesized as novel probes for studying the cis/trans isomerization of the amino acylproline peptide bond. The N-Boc-protected target compounds were obtained as optically pure material starting from (2S,3S)-3-hydroxyproline.