Title of article
An expedient synthesis of the amide analog of the potent antifungal lipopeptidolactone FR901469
Author/Authors
Barrett، نويسنده , , David J. Tanaka، نويسنده , , Akira and Fujie، نويسنده , , Akihiko and Shigematsu، نويسنده , , Nobuharu and Hashimoto، نويسنده , , Michizane and Hashimoto، نويسنده , , Seiji، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
703
To page
705
Abstract
An expedient synthesis of the lactam analog (2) of the 40-membered lipopeptidolactone antifungal antibiotic, FR901469 (1), is described. The key steps in this synthesis are a novel biotransformation of the natural product to produce the highly versatile linear peptide building block 3, and efficient formation of the 40-membered ring by macrolactamization under high-dilution conditions.
Keywords
peptides and polypeptides , Macrocycles , microbial reactions , Antifungals
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1641413
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