Title of article
The synthesis and cytotoxicity of fructose-1-SNAP, a novel fructose conjugated S-nitroso nitric oxide donor
Author/Authors
Hou، نويسنده , , Yongchun and Wu، نويسنده , , Xuejun and Xie، نويسنده , , Wenhua and Braunschweiger، نويسنده , , Paul K. and Wang، نويسنده , , Peng G، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
5
From page
825
To page
829
Abstract
An efficient synthetic strategy has been developed for the synthesis of a novel fructose conjugated S-nitroso nitric oxide donor, fructose-1-S-nitroso-N-acetylpenicillamine. This compound showed similar cytotoxicity as the first generation fructose-SNAP, fructose-2-SNAP. A 5- and 26-fold increased cytotoxicity was observed compared to glucose-2-SNAP and SNAP against DU-145 human prostate cancer cells in vitro.
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1641509
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