Title of article
Solid phase synthesis of enantiomerically pure polyhydroxyvalerolactams
Author/Authors
Pirَ، نويسنده , , Jordi and Rubiralta، نويسنده , , Mario and Giralt، نويسنده , , Ernest and Diez، نويسنده , , Anna، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
871
To page
873
Abstract
A general method for the solid phase synthesis of type 2 3,4,5-trihydroxypiperidin-2-ones is described. Amination of d-ribonolactone 4 was accomplished using a Mitsunobu reaction, and type 7 aminolactone underwent direct lactamisation upon treatment with NaOAc. For the solid phase synthesis, the aminoacid was anchored directly to a TentaGel® resin, and the lactamisation step was concomitant with the cleavage from the resin.
Keywords
hydroxylactams , Solid phase synthesis , hydroxypiperidines , azasugars
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1641545
Link To Document