Title of article
Novel trifluoroethanol mediated synthesis of benzo[a]pyrene 7,8-diol 9,10-epoxide adducts at the N2-position of deoxyguanosine and the N6-position of deoxyadenosine
Author/Authors
Ramesha، نويسنده , , Andagar R and Kroth، نويسنده , , Heiko and Jerina، نويسنده , , Donald M، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
3
From page
1003
To page
1005
Abstract
The exocyclic amino groups of deoxyadenosine and deoxyguanosine readily add to C-10 of the benzo[a]pyrene 7,8-diol 9,10-epoxides at room temperature overnight in trifluoroethanol. Whereas the dG adducts are obtained as a mixture of cis- and trans-opened diastereomers, the dA adducts arise exclusively by cis-opening.
Keywords
Trifluoroethanol , dA and dG adducts , diol epoxides
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1641659
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