Title of article
Chiral monoaminoalcohols and diaminoalcohols of squaric acid: new catalysts for the asymmetric reduction of ketones by borane
Author/Authors
Zhou، نويسنده , , Haibing and Lü، نويسنده , , Shoumao and Xie، نويسنده , , Rugang and Chan، نويسنده , , Albert S.C and Yang، نويسنده , , Teng-Kuei، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
1107
To page
1110
Abstract
Two series of new chiral ligands, squaric acid aminoalcohols and C2-symmetric squaric acid diaminoalcohols have been synthesized. The chiral oxazaborolidines formed in situ from these ligands have been used in the enantioselective borane reduction of prochiral ketones and diketones to afford alcohol products with up to 99% enantiomeric excesses. The structures of the ligands have an obvious effect on the ee of the resulting alcohols.
Keywords
Enantioselective reduction , aminoalcohol and diaminoalcohol derivatives of squaric acid , oxazaborolidines , ketones
Journal title
Tetrahedron Letters
Serial Year
2001
Journal title
Tetrahedron Letters
Record number
1641791
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